Enhancing the cytotoxic activity of anticancer Pt(IV) complexes by introduction of lonidamine as an axial ligandстатья
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Дата последнего поиска статьи во внешних источниках: 30 декабря 2016 г.
Аннотация:The synthesis and in vitro cytotoxicity of a series of Pt(IV)
complexes with lonidamine as a ligand coordinated in axial position
are described. The lonidamine was found to affect strongly the in
vitro cytotoxic activity of these novel complexes, lowering the IC50
values down to the nanomolar range. Lipophilicity assessed in terms
of log P showed no direct correlation with cytotoxicity.