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Effect of several flavonoid-containing plant preparations on activity of mitochondrial ATP-dependent potassium channelстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 октября 2016 г.
- Авторы: Mironova G.D., Shigaeva M.I., Belosludtseva N.V., Gritsenko E.N., Belosludtsev K.N., Germanova E.L., Lukyanova L.D.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 146
- Номер: 2
- Год издания: 2008
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 229
- Последняя страница: 233
- DOI: 10.1007/s10517-008-0255-7
- Аннотация: Flavonoid-containing plant preparations (water soluble extracts of Pentaphylloides fruticosa [Extralife], Emblica officinalis Gaerth [Amla], and Bergenia crassifolia [Bergenia]) produced a dose-dependent and tissue-specific effect on activity of mitochondrial ATP-dependent potassium channel. The effect of these preparations was biphasic (activation and inhibition). The activating effect of Extralife was one order of magnitude higher than that of Amla and Bergenia and was observed in a wider concentration range. The activating effect of preparations was abolished by inhibitors of the mitochondrial ATP-dependent potassium channel, which attested to specificity of their influence on mitochondrial channel. Under in vivo conditions, the antihypoxic effect of Extralife was partially abolished by mitochondrial ATP-dependent potassium channel inhibitor 5-hydroxydecanoate.
- Добавил в систему: Белослудцев Константин Николаевич