The Hydrolytic Destruction of Modified Cellulosic Materials in Conditions Simulating a Purulent Woundстатья
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Дата последнего поиска статьи во внешних источниках: 21 октября 2020 г.
Аннотация:The development of new effective agents for purulent wounds treatment remains one of the most priority tasks of modern Biomedicine. An important aspect of ensuring the wound healing process is the selection of appropriate dressings. The right choice allows you to provide proper supportive therapy that accompanies the treatment of the root cause. Unlike cotton cellulose, dialdehyde cellulose undergoes significant hydrolytic and biological degradation in the human body under physiological conditions. Modern dressings are developed and produced on the basis of dialdehyde cellulose, chitosan, and various therapeutic agents (including enzymes). The kinetics of hydrolytic destruction of materials based on modified cellulose was studied. Using UV- and IR- spectroscopy, and dynamic light scattering methods, the decomposition of various cellulose matrices based on cotton medical gauze (1/15M phosphate buffer solution, pH 6.2, 37ºC) was studied. The properties of the cellulose carrier’ degradation products also were investigated. Their biological properties have been studied. It was found that the products of hydrolytic destruction of dialdehyde cellulose have antioxidant properties. The degradation of the cellulose carrier increases with the raising of cellulose modification degree, temperature, time, and pH of the solution. Chitosan stabilization of the oxidized cellulose carrier was found.