METAL-BASED PHYSIOLOGICALLY ACTIVE COMPOUNDS –CANDIDATES FOR ANTICANCER DRUGS

Авторы: Milaeva Elena R., Dmitry Shpakovsky, Alexey Nazarov
Сборник: Internatinal Symposium on Medicinal chemistry, Manchester, UK, Aug. 28- Sept. 1, 2016
Тезисы
Год издания: 2016
Место издания: Manchester, UK
Первая страница: 278
Аннотация: Nowadays the attention given to medicinal inorganic chemistry, which can be defined as the research field involving the use of metal-containing compounds for medicinal purposes, has steadily grown over the last years, due to their extensive application in pharmaceutical market. A short review represents the main approaches to the design of protein target-oriented metal-based physiologically active compounds: the synthesis of known metal-based drugs analogues, the incorporation of organic pharmacophore groups into the ligand environment of metal, the use of organic drugs molecules as ligands in metal complexes. The protein target-focused syhthesis of novel metal compounds (M = Sn, Au, Ru), their physico-chemical properties and biological activity will be discussed. The biological activity has been studied in in vitro, ex vivo, in vivo experiments.
Добавил в систему: Шпаковский Дмитрий Борисович

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