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Antihypoxic action of Panax Japonicus, Tribulus Terrestris and Dioscorea Deltoidea cell cultures in silico and animal studiesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 сентября 2020 г.
- Авторы: Lagunin A., Povydysh M., Ivkin D., Luzhanin V., Krasnova M., Okovityi S., Nosov A., Titova M., Tomilova S., Filimonov D., Poroikov V.
- Журнал: Molecular informatics
- Том: 39
- Номер: 11
- Год издания: 2020
- Издательство: Wiley-VCH Verlag
- Местоположение издательства: Weinheim, Germany, Germany
- Первая страница: 1
- Последняя страница: 12
- Номер статьи: e2000093
- DOI: 10.1002/minf.202000093
- Аннотация: Abstract: Chemical diversity of secondary metabolitesprovides a considerable variety of pharmacological actionswith a significant extension due to their combinations inplant extracts. Production of plant-derived medicinal productsin cell cultures has advantages because of the efficientuse of different biotic and abiotic elicitors and bettercontrol of the developmental processes. Using PASSsoftware, we predicted biological activity spectra forphytoconstituents identified in cell cultures of Panaxjaponicus (12 molecules), Tribulus terrestris (4 molecules),and Dioscorea deltoidea (3 molecules). Mechanisms of actionassociated with the antihypoxic effect were predicted forthe majority of molecules. PharmaExpert software allowedanalyzing possible synergistic or additive effects of thecombinations of phytoconstituents associated with theantihypoxic action. Experimental studies of the antihypoxiceffect of the plants’ extracts in water and ethanol havebeen performed in 3 animal models: Acute asphyctichypoxia (AAH), Acute haemic hypoxia (AHeH), and Acutehistotoxic hypoxia (AHtH). Effects of Panax japonicus andTribulus terrestris preparations exceeded the activity of thereference drug Mexidol in the AHtH model. In the AHeHmodel, all preparations demonstrated moderate activity;the most potent has been observed for Dioscorea deltoidea.Thus, we found that experimental studies in animal modelshave confirmed the in silico prediction
- Добавил в систему: Носов Александр Михайлович