Antihypoxic action of Panax Japonicus, Tribulus Terrestris and Dioscorea Deltoidea cell cultures in silico and animal studies

Lagunin, A.; Povydysh, M.; Ivkin, D.; Luzhanin, V.; Krasnova, M.; Okovityi, S.; Nosov, A.; Titova, M.; Tomilova, S.; Filimonov, D.; Poroikov, V.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 сентября 2020 г.

Авторы: Lagunin A., Povydysh M., Ivkin D., Luzhanin V., Krasnova M., Okovityi S., Nosov A., Titova M., Tomilova S., Filimonov D., Poroikov V.
Журнал: Molecular informatics
Том: 39
Номер: 11
Год издания: 2020
Издательство: Wiley-VCH Verlag
Местоположение издательства: Weinheim, Germany, Germany
Первая страница: 1
Последняя страница: 12
Номер статьи: e2000093
DOI: 10.1002/minf.202000093
Аннотация: Abstract: Chemical diversity of secondary metabolitesprovides a considerable variety of pharmacological actionswith a significant extension due to their combinations inplant extracts. Production of plant-derived medicinal productsin cell cultures has advantages because of the efficientuse of different biotic and abiotic elicitors and bettercontrol of the developmental processes. Using PASSsoftware, we predicted biological activity spectra forphytoconstituents identified in cell cultures of Panaxjaponicus (12 molecules), Tribulus terrestris (4 molecules),and Dioscorea deltoidea (3 molecules). Mechanisms of actionassociated with the antihypoxic effect were predicted forthe majority of molecules. PharmaExpert software allowedanalyzing possible synergistic or additive effects of thecombinations of phytoconstituents associated with theantihypoxic action. Experimental studies of the antihypoxiceffect of the plants’ extracts in water and ethanol havebeen performed in 3 animal models: Acute asphyctichypoxia (AAH), Acute haemic hypoxia (AHeH), and Acutehistotoxic hypoxia (AHtH). Effects of Panax japonicus andTribulus terrestris preparations exceeded the activity of thereference drug Mexidol in the AHtH model. In the AHeHmodel, all preparations demonstrated moderate activity;the most potent has been observed for Dioscorea deltoidea.Thus, we found that experimental studies in animal modelshave confirmed the in silico prediction
Добавил в систему: Носов Александр Михайлович

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Antihypoxic action of Panax Japonicus, Tribulus Terrestris and Dioscorea Deltoidea cell cultures in silico and animal studiesстатья

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