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The antioxidant activity of cyclohistidylprolineстатья
- Авторы: Shvachkin Iu P., Korshunova G.A., Bavykina N.I., Guliaeva N.V., Dupin A.M.
- Журнал: Biulleten' eksperimental'noi biologii i meditsiny
- Том: 108
- Номер: 12
- Год издания: 1989
- Первая страница: 671
- Последняя страница: 3
- Аннотация: A cyclohistidyl-proline, cyclopeptide possessing a hormonal and neurotrophic activity is shown to be an inhibitor of the (Fe + ascorbic acid)-induced peroxidation of membrane lipids, its effect being dependent on its concentration. Inhibition of the malondialdehyde formation by cyclohistidil-proline is accompanied by protection of the membrane bound Ca-pump. In the test of the free radical cumole oxidation antioxidative effect of cyclohistidyl-proline is 4 times higher than that of the hydrophilic antioxidant carnosine. After peritoneal injection of cyclohistidil-proline (15 mg/kg of body weight) to rats the stationary level of thiobarbituric acid reactive products in rat brain or serum is pronouncedly decreased, this effect being in progress up to 6 h after injection. Antioxidative action of cyclohistidyl-proline suggests to be on the basis of a variety of its biological effects.
- Добавил в систему: Коршунова Галина Анатольевна