Аннотация:In connection with the emergence of new antibiotic resistantstrains of bacteria in the world, the problem of treatment of sep-sis has become more acute. One of the key tasks in the treatmentof severe sepsis is the ability to remove bacterial endotoxins fromthe patient’s bloodstream. A high concentration of bacterialendotoxins in the human blood disrupts the normal functioningof the immune system and dramatically worsens the patient’s condition. The removal of endotoxins is carried out in extracor-poreal therapy procedures using sorbents. Thus, the developmentof new effective sorbents for the removal of endotoxin is animportant task. Lysozyme is able to bind with the components ofthe surface of a bacterial cell, so we have suggested that a lyso-zyme based sorbent can potentially be able to bind bacteriallipopolysaccharides. The sorbent made by us contains 14–15 mgof a covalently immobilized lysozyme per 1 g of an insolublepolysaccharide matrix (cross-linked agarose). This sorbent showshigh efficiency of endotoxin binding from solution: 50 mL of sor-bent can remove up to 88% Escherichia coli endotoxin or 84%Pseudomonas aeruginosa endotoxin from a 500 mL solution withan endotoxin concentration of 500 EU / mL (50 ng / mL).