Strategies for Solubility Enhancement of Anthelminticsстатья
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Дата последнего поиска статьи во внешних источниках: 30 сентября 2020 г.
Аннотация:Most drug substances are poorly soluble in water so that their efficacies must be improved by increasing thedosage, which not only creates economic problems but also increases the toxicity of the future medicine.These problems can be solved by developing various dosage forms, which involves additional financial costs,complicates the technology, increases development times to introduce the future medicine, etc. Another approachto improving the solubility of such drug substances is the development of methods and technologiesfor producing solid dispersions of these drug substances with excipients (polymers, dispersants, surfactants,etc.). The present review covers the development and application of mechanochemical technology to modifysparingly soluble anthelmintic drugs. The technology consists essentially of joint mechanical treatment of adrug substance and polymer in grinder-activators of controlled energy. This technology uses one stage andavoids the use of solvents, heating, evaporation, etc. The resulting solid dispersions include supramolecularsystems with increased solubility and better bioavailability and are also highly active with reduced consumptionof the active ingredients.