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Frontiers in urethra regeneration: current state and future perspectiveстатья
- Авторы: Vasyutin Igor, Denis Butnaru, Alexey Lyundup, Timashev Peter, Vinarov Andrei, Kuznetsov Sergey, Atala Anthony, Zhang Yuanyuan
- Журнал: Biomedical Materials
- Год издания: 2020
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Аннотация: Despite the positive achievements attained, the treatment of male urethral strictures and hypospadiases still remains a challenge, particularly, in cases of severe urethral defects. Complication rate and need for additional interventions in such cases are the highest. Also, shortage of autologous tissue for graft harvesting and significant morbidity on the place of harvesting present a problem and often lead to staged treatment. Tissue engineering provides a promising alternative to the current sources of grafts for urethroplasty. Since the first experiments in urethral substitution with tissue engineered grafts, this topic in regenerative medicine has grown remarkably, as many different types of tissue engineered grafts and approaches in graft design have been suggested and tested in vivo. However, there have been only several clinical trials of tissue engineered grafts in urethral substitution with hardly more than hundred patients overall. This indicates that the topic is still in its inception, and the searching for the best graft design is continuing. The current review focuses on the state of art in urethral regeneration with tissue engineering technology. It gives comprehensive overview of components of the tissue engineered graft and overview of steps in the graft development. Different cell sources, types of scaffolds, assembling approaches, options for vascularization enhancement and preclinical models are considered.
- Добавил в систему: Тимашев Петр Сергеевич