Regioselectivity of the Chan-Lam coupling of ambident nitropyrazoles with trans-styrylboronic acidстатьяИсследовательская статья
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Дата последнего поиска статьи во внешних источниках: 8 сентября 2020 г.
Аннотация:Regioselectivity of the Chan-Lam coupling of ambident nitropyrazoles with trans-styrylboronic acid depends on the base and catalyst nature and can vary the N(1)/N(2)-isomer ratio from similar to 2 : 1 to similar to 1 : 2. 2-Methyl-4-nitro- and 2,4-dinitroimidazoles are unreactive in this reaction. The structure of N(1)/N(2) isomers was elucidated by NOE measurements and by the comparison of experimental and DFT calculated C-13 NMR chemical shifts.