Could multi-responsive hollow shell-shell nanocontainers offer an improved strategy for drug delivery?статья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 4 декабря 2016 г.
Аннотация:In this editorial, we report a new concept using responsive nanocontainers for drug delivery, namely employing hollow nanogels with two polymer shells that have different
volume phase transition temperatures. The temperature responsive swelling and collapse
of the inner shell control the uptake, storage in the void and release of guest (macro)molecules, while the swelling of the outer shell controls the size of the void and the colloidal stability of the nanogels. In other words, the inner shell plays a role of a membrane of variable permeability for the molecules while the outer shell always serves as permeable membrane. These new multishell nanoparticles can be further functionalized. Their different layers may fulfill distinct requirements during transport, uptake and targeted release of pharmaceutical molecules. Therefore, two-shell hollow nanocontainers may have great potential to be used as drug delivery carriers for different applications.