Photonic toolbox for fast real-time polymerase chain reactionстатья
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Дата последнего поиска статьи во внешних источниках: 16 сентября 2020 г.
Аннотация:We present an optical scientist vision for a photonic platform for real-time polymerase chainreaction (qPCR) and reverse-transcription qPCR (qRT-PCR) that integrates a rapid-cyclefiber-optic PCR chamber with feedback-controlled laser heating, online fluorometric detectionof PCR products, and all-optical thermometry using an optical readout from color centers ofdiamond nanoparticles. We show that, with a careful optimization of laser-induced heating andheat-removal geometry, this approach can radically shorten the qPCR thermal cycle relative tostandard PCR systems, paving the way toward credit-card-size testing kits for fast point-of-careinfection diagnosis. Faster photonic qPCR/qRT-PCR will enable a rapid and highly specificearly detection of infections, including new viruses, such as SARS-CoV-2 at very earlystages—in most cases, even before the onset of disease, providing much-needed lead time forearly treatment and disease spread prevention.