Properties of hybridization isotherms upon binding of ligands on microchipsстатья
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Дата последнего поиска статьи во внешних источниках: 4 февраля 2014 г.
Аннотация:A simple thermodynamic model describing the microarray oligo-target hybridization has been constructed. The relationship between the hybridization signal intensity and Gibbs free energy for oligo-target duplex formation has been considered. The behavior of this function, which we called energetical hybridization isotherm, in response to target concentration change was modeled at different ratios of oligo-probes/target concentrations. The results of modeling were compared with the relevant and currently available data from microarray adsorption experiments.