Аннотация:The termination of the protein biosynthesis on the ribosome has complex mechanism. Eukaryotic class-1 release factor (eRF1) plays a key role in this process. Protein consist of three domains. While roles of the N and M domains are well confirmed, the mechanism of eRF1 regulation via C-domain remains unclear. New structural information may help to clarify details of the mechanism of eRF1 regulation. Presented results of NMR signal assignments of the C-terminal domain of eRF1.