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ROLE OF INFLAMMATORY AND SYNAPTIC PLASTICITY GENES IN INDIVIDUAL DIFFERENCES IN COGNITIVE ABILITIESстатья
- Авторы: Kazantseva A., Takhirova Z., Lobaskova M., Enikeeva R., Mustafin R., Tikhomirova T., Davydova Yu, Malykh S., Khusnutdinova E.
- Сборник: Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06–10 July 2020, Novosibirsk, Russia); Abstracts
- Год издания: 2020
- Место издания: ICG SB RAS Novosibirsk
- Первая страница: 281
- Последняя страница: 282
- DOI: 10.18699/BGRS/SB-2020-178
- Аннотация: The mechanisms underlying individual cognitive functioning are complex, and genetic and epigenetic factors play a significant role. Considering the possible involvement of inflammatory pathways and synaptic plasticity in cognitive functioning, the present study aimed to estimate the main effect of BDNF, IL1B, CRP, and TNF gene polymorphisms together with gene-environment interactions in manifestation of individual differences in several cognitive abilities in young adults. Multiple linear regression conducted on the data obtained from 897 mentally healthy young adults (79% women; 19.74±1.51 years) of Caucasian origin revealed the association of TNF rs1041981 A-allele and ability of 3D mental rotation, and general intelligence (factor “g”). Moreover, significant interactive effects of TNF rs1041981 and CRP rs3093077 and several peculiarities of childhood rearing on cognitive functioning were demonstrated.
- Добавил в систему: Жданова Галина Евгеньевна