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The alginate-chitosan composite sponges with biogenic Ag nanoparticles produced by combining of cryostructuration, ionotropic gelation and ion replacement methodsстатья
- Авторы: Gordienko M.G., Palchikova V.V., Kalenov S.V., Lebedev E.A., Belov A.A., Menshutina N.V.
- Журнал: International Journal of Polymeric Materials and Polymeric Biomaterials
- Год издания: 2020
- Издательство: Taylor & Francis
- Местоположение издательства: United Kingdom
- DOI: 10.1080/00914037.2020.1798439
- Аннотация: Uncontrolled bleeding causes more than 30% of deaths due to injuries worldwide. Modern hemostaticmaterials based on synthetic and biological macromolecules focus mainly on the time priorto hemostasis, but the prevention of a bacterial infection is also crucial for increasing survival.Silver is known to exhibit potent antimicrobial activity and strong biocidal effects against varioustypes of bacteria. A new method for producing of composite sponges with a pronounced antimicrobialeffect based on such biological polymers as alginate and chitosan with the addition ofsilver nanoparticles has been proposed. The method is based on the combination of cryostructuring,ionotropic gelation and ion substitution methods during the formation of the macroporousstructure of the sponge at the gelation stage with subsequent freeze drying. Silver nanoparticlesisolated by three fungal cultures were introduced into the sponges in low concentrations. Thealginate–chitosan–composite sponges with Ag nanoparticles showed high sorption capacity,microporous structure and increased antimicrobial activity compared to a composite sponge withoutthe inclusion of silver nanoparticles.
- Добавил в систему: Белов Алексей Алексеевич