N-Pyridyl-Substituted Carboxypiperidine Amides: A New Class of Prokaryote Translation Inhibitorsстатья
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Дата последнего поиска статьи во внешних источниках: 2 декабря 2020 г.
Аннотация:High-throughput screening identified a new class of antibacterial compounds based on N-pyridyl-substitutedp- and m-carboxypiperidine amides. Constructs with the two reporter genes RFP and Katushka2S allowed thedetection of compounds that inhibit protein translation against DNA biosynthesis. Some agents of this classdemonstrated antibacterial activity by inhibiting translation. The most promising compound had an MIC of12 g/mL. Thus, this class could become a valuable platform for developing new compounds with higher antibacterialactivity and selectivity.