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The nature and clinical significance of atypical mononuclear cells in infectious mononucleosis caused by the Epstein-Barr virus in childrenстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 4 июня 2021 г.
- Авторы: Fedyanina O.S., Filippova A.E., Demina О.I., Zhuliabina О.А., Tikhomirov D.S., Filatov A.V., Chebotareva T.A., Kuznetsova S.A.
- Журнал: Journal of Infectious Diseases
- Год издания: 2020
- Издательство: University of Chicago Press
- Местоположение издательства: United States
- Первая страница: 1
- Последняя страница: 8
- DOI: 10.1093/infdis/jiaa601
- Аннотация: Atypical mononuclear cells (AM) appear in significant numbers in peripheral blood of patients with Epstein-Barr virus (EBV)- associated infectious mononucleosis (IM). We investigated the number and lineage-specific clusters of differentiation (CD) expression of atypical mononuclear cells in 110 children with IM using the anti-CD antibody microarray for panning leukocytes by their surface markers prior to morphology examination. The AM population consisted primarily of CD8+ T cells with a small fraction (0%–2% of all lymphocytes) of CD19+ B lymphocytes. AM amount in children with mononucleosis caused by primary EBV infection was significantly higher than for IM caused by EBV reactivation or other viruses and constituted 1%–53% of all peripheral blood mononuclear cells compared to 0%–11% and 0%–8%, respectively. Children failing to recover from classic IM associated with primary EBV infection within 6 months had significantly lower percentage of CD8+ AM compared to patients with normal recovery rate.
- Добавил в систему: Филиппова Анна Евгеньевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Mononukleoz_angl.pdf | 391,4 КБ | 2 декабря 2020 [Anna_Z] |