Comparative Immunological Study in Mice of Inactivated Influenza Vaccines Used in the Russian Immunization Program

Shanko, A.; Shuklina, M.; Kovaleva, A.; Zabrodskaya, Y.; Vidyaeva, I.; Shaldzhyan, A.; Fadeev, A.; Korotkov, A.; Zaitceva, M.; Stepanova, L.; Tsybalova, L.; Kordyukova, L.; Katlinski, A.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 января 2021 г.

Авторы: Shanko Andrei, Shuklina Marina, Kovaleva Anna, Zabrodskaya Yana, Vidyaeva Inna, Shaldzhyan Aram, Fadeev Artem, Korotkov Alexander, Zaitceva Marina, Stepanova Liudmila, Tsybalova Liudmila, Kordyukova Larisa, Katlinski Anton
Журнал: VACCINES
Том: 8
Номер: 4
Год издания: 2020
Первая страница: 756
DOI: 10.3390/vaccines8040756
Аннотация: A series of commercial inactivated influenza vaccines (IIVs) used in the Russian National Immunization Program were characterized to evaluate their protective properties on an animal model. Standard methods for quantifying immune response, such as hemagglutination inhibition (HAI) assay and virus neutralization (VN) assay, allowed us to distinguish the immunogenic effect of various IIVs from that of placebo. However, these standard approaches are not suitable to determine the role of various vaccine components in immune response maturation. The expanded methodological base including an enzyme-linked immunosorbent assay (ELISA) and a neuraminidase ELISA (NA-ELISA) helped us to get wider characteristics and identify the effectiveness of various commercial vaccines depending on the antigen content. Investigations conducted showed that among the IIVs tested, Ultrix®, Ultrix® Quadri and VAXIGRIP® elicit the most balanced immune response, including a good NA response. For Ultrix®, Ultrix® Quadri and SOVIGRIPP® (FORT LLC), the whole-virus specific antibody subclass IgG1, measured in ELISA, seriously prevailed over IgG2a, while, for VAXIGRIP® and SOVIGRIPP® (NPO Microgen JSC) preparations, the calculated IgG1/IgG2a ratio was close to 1. So, the immune response varied drastically across different commercial IIVs injected in mice.
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Comparative Immunological Study in Mice of Inactivated Influenza Vaccines Used in the Russian Immunization Programстатья

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