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Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertensionстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 декабря 2020 г.
- Авторы: Polina Iuliia, Domondon Mark, Fox Rebecca, Sudarikova Anastasia V., Troncoso Miguel, Vasileva Valeriia Y., Kashyrina Yuliia, Gooz Monika Beck, Schibalski Ryan S., DeLeon-Pennell Kristine Y., Fitzgibbon Wayne R., Ilatovskaya Daria V.
- Журнал: American Journal of Physiology - Renal Physiology
- Том: 319
- Номер: 1
- Год издания: 2020
- Издательство: American Physiological Society
- Местоположение издательства: United States
- Первая страница: F63
- Последняя страница: F75
- DOI: 10.1152/ajprenal.00125.2020
- Аннотация: Diuretics and renin-angiotensin system blockers are often insufficient to control the blood pressure (BP) in salt-sensitive (SS) subjects. Abundant data support the proposal that the level of atrial natriuretic peptide may correlate with the pathogenesis of SS hypertension. We hypothesized here that increasing atrial natriuretic peptide levels with sacubitril, combined with renin-angiotensin system blockage by valsartan, can be beneficial for alleviation of renal damage in a model of SS hypertension, the Dahl SS rat. To induce a BP increase, rats were challenged with a high-salt 4% NaCl diet for 21 days, and chronic administration of vehicle or low-dose sacubitril and/or valsartan (75 μg/day each) was performed. Urine flow, Na+ excretion, and water consumption were increased on the high-salt diet compared with the starting point (0.4% NaCl) in all groups but remained similar among the groups at the end of the protocol. Upon salt challenge, we observed a mild decrease in systolic BP and urinary neutrophil gelatinase-associated lipocalin levels (indicative of alleviated tubular damage) in the valsartan-treated groups. Sacubitril, as well as sacubitril/valsartan, attenuated the glomerular filtration rate decline induced by salt. Alleviation of protein cast formation and lower renal medullary fibrosis were observed in the sacubitril/valsartan- and valsartan-treated groups, but not when sacubitril alone was administered. Interestingly, proteinuria was mildly mitigated only in rats that received sacubitril/valsartan. Further studies of the effects of sacubitril/valsartan in the setting of SS hypertension, perhaps involving a higher dose of the drug, are warranted to determine if it can interfere with the progression of the disease.
- Добавил в систему: Васильева Валерия Юрьевна