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Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour. Orphanet journal of rare diseasesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 декабря 2020 г.
- Авторы: Kuznetsova V., Tyakht A., Akhmadishina L., Odintsova V., Klimenko N., Kostryukova E., Vakhitova M., Grigoryeva T., Malanin S., Vladimirtsev V., Nikitina R., Volok V., Osakovskiy V., Sivtseva T., Platonov F., Alexeev D., Karganova G.
- Журнал: Orphanet Journal of Rare Diseases
- Том: 15
- Номер: 1
- Год издания: 2020
- Издательство: BioMed Central
- Местоположение издательства: London
- Номер статьи: 327
- DOI: 10.1186/s13023-020-01612-4
- Аннотация: Background: Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been proposed regarding its etiology, including infectious agents, genetics, environmental factors, and immunopathology. Each of these hypotheses has been supported to some extent by epidemiological and experimental data. Nevertheless, none of them has been decisively proven. Gut microbiome is one of the factors that might be involved in VE pathogenesis.Results: Here we performed a pilot survey of the stool microbiomes of Yakut subjects with VE (n = 6) and without VE (n = 11). 16S rRNA sequencing showed that in comparison with the control group, the Yakuts with VE had increased proportions of Methanobrevibacter and Christensenella, which are reported to be linked to body mass index, metabolism, dietary habits and potentially to neurodegenerative disorders. The identified associations suggest that the microbiome may be involved in VE. Overall, the Yakut microbiome was quite specific in comparison with other populations, such as metropolitan Russians and native inhabitants of the Canadian Arctic.Conclusions: Describing the gut microbiome of indigenous human populations will help to elucidate the impact of dietary and environmental factors on microbial community structure and identify risks linked to the lifestyles of such groups as well as endemic diseases.Keywords: 16S rRNA sequencing; Gut microbiome; Methanobrevibacter; Microbiome-gut-brain axis; Viliuisk encephalomyelitis; Yakuts.
- Добавил в систему: Волок Виктор Петрович