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The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factorстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 января 2021 г.
- Авторы: Belyi Alexei A., Alekseev Alexey A., Fedintsev Alexander Y., Balybin Stepan N., Proshkina Ekaterina N., Shaposhnikov Mikhail V., Moskalev Alexey A.
- Журнал: ANTIOXIDANTS
- Том: 9
- Номер: 12
- Год издания: 2020
- Первая страница: 1239
- Последняя страница: 1239
- DOI: 10.3390/antiox9121239
- Аннотация: We studied how aging affects the ability of Drosophila melanogaster to tolerate various types of stress factors. Data were obtained on the resistance of D. melanogaster to oxidative and genotoxic (separately paraquat, Fe3+, Cu2+, and Zn2+ ions), proteotoxic (hyperthermia, Cd2+ ions), and osmotic (NaCl) stresses, starvation, and infection with the pathological Beauveria bassiana fungus at different ages. In all cases, we observed a strong negative correlation between age and stress tolerance. The largest change in the age-dependent decline in survival occurred under oxidative and osmotic stress. In most experiments, we observed that young Drosophila females have higher stress resistance than males. We checked whether it is possible to accurately assess the biological age of D. melanogaster based on an assessment of stress tolerance. We have proposed a new approach for assessing a biological age of D. melanogaster using a two-parameter survival curve model. For the model, we used an algorithm that evaluated the quality of age prediction for different age and gender groups. The best predictions were obtained for females who were exposed to CdCl2 and ZnCl2 with an average error of 0.32 days and 0.36 days, respectively. For males, the best results were observed for paraquat and NaCl with an average error of 0.61 and 0.68 days, respectively. The average accuracy for all stresses in our model was 1.73 days.
- Добавил в систему: Алексеев Алексей Алексеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Текст статьи | antioxidants-09-01239.pdf | 1,3 МБ | 9 декабря 2020 [alex3] |
| 2. | Supplementary materials - интересные графики | antioxidants-09-01239-s001.zip | 5,4 МБ | 9 декабря 2020 [alex3] |