Местоположение издательства:Cold Spring Harbor, NY, United States
Первая страница:116
Последняя страница:116
Аннотация:Before transcription, PARP1 binding to nucleosomes containing double-strandDNA breaks (DSBs) induces an uncoiling of nucleosomal DNA (4).Twodistinct types of PARP1 binding to mononucleosomes were detected usingspFRET: binding to DSBs or binding to core nucleosome, respectively.Surprisingly, only the latter type of binding of PARP1 induces the reversibleuncoiling of nucleosomal DNA that is independent of catalytic activity ofPARP1. The data suggest that PARP1-induced nucleosome unfolding isinduced by H1-like binding of PARP1 to nucleosomes