Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer

Kolovskaya, O.S.; Zamay, T.N.; Zamay, G.S.; Babkin, V.A.; Medvedeva, E.N.; Neverova, N.A.; Kirichenko, A.K.; Zamay, S.S.; Lapin, I.N.; Morozov, E.V.; Sokolov, A.E.; Narodov, A.A.; Fedorov, D.G.; Tomilin, F.N.; Zabluda, V.N.; Alekhina, Y.; Lukyanenko, K.A.; Glazyrin, Y.E.; Svetlichnyi, V.A.; Berezovski, M.V.; Kichkailo, A.S.

Авторы: Kolovskaya Olga S., Zamay Tatiana N., Zamay Galina S., Babkin Vasily A., Medvedeva Elena N., Neverova Nadezhda A., Kirichenko Andrey K., Zamay Sergey S., Lapin Ivan N., Morozov Evgeny V., Sokolov Alexey E., Narodov Andrey A., Fedorov Dmitri G., Tomilin Felix N., Zabluda Vladimir N., Alekhina Yulia, Lukyanenko Kirill A., Glazyrin Yury E., Svetlichnyi Valery A., Berezovski Maxim V., Kichkailo Anna S.
Журнал: Cancers
Том: 12
Номер: 1
Год издания: 2020
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 216
Последняя страница: 216
DOI: 10.3390/cancers12010216
Аннотация: Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field.
Добавил в систему: Алехина Юлия Александровна

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Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancerстатья

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