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Cytochrome c potentiates fatty acid-induced cyclosporin A-sensitive permeability transition in liver mitochondriaстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.
- Авторы: Amerkhanov Z.G., Mokhova E.N.
- Журнал: Biochemistry (Moscow)
- Том: 62
- Номер: 12
- Год издания: 1998
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1429
- Последняя страница: 1434
- Аннотация: Addition of 0.5-5 microM cytochrome c and 30 microM lauric acid to rat liver mitochondria stimulated the respiration rate. Stimulation of respiration by cytochrome c was prevented by cyclosporin A and was not observed in the absence of lauric acid. High amplitude swelling of mitochondria in the presence of lauric acid was also potentiated by cytochrome c; this effect was prevented by cyclosporin A or by EGTA. Polylysine (0.35 microM) induced cyclosporin A-insensitive high amplitude swelling of mitochondria. Polylysine-induced swelling was stimulated by lauric acid and cytochrome c; the effect was prevented by cyclosporin A. Incubation of mitochondria with 30 microM lauric acid resulted in an increase in cytochrome c concentration in the incubation medium. Added cytochrome c is supposed to potentiate the laurate-induced cyclosporin A-sensitive permeability transition in cytochrome c-depleted mitochondria.
- Добавил в систему: Мохова Елена Николаевна