Аннотация:The intracellular motility of the huge amoeboid cell, Physarum plasmodium, is defined by autowave processes, which are caused by interaction of actomyosin-based contractile apparatus in ectoplasm and intracellular endoplasmic flows. With the use of cell tensiometry and laser Doppler spectroscopy technique the autowave regimes in plasmodial strands (which look like blood-vessels) was investigated under the conditions when endogenous contractile rhythm in a part of the strand was eliminated by respiratory inhibitors. Mathematical model for ectoplasm contraction waves and shuttle endoplasm streaming in the strand is presented. Solutions of the model expanded to simulate the case of non- uniform parameter distribution satisfactorily agree with the experimentally observed effects of the respiratory inhibitors.