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Immobilization of amikacin on dextran: biocomposite materials that release an antibiotic in the presence of bacterial dextranaseстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 января 2021 г.
- Авторы: Dyatlov Valerie, Seregina Tatiana, Luss Anna, Zaitsev Vladimir, Artyukhov Alexander, Shtilman Mikhail, Chumakova Anna, Kushnerev Kirill, Tsatsakis Aristidis, Mezhuev Yaroslav
- Журнал: Polymer International
- Том: 70
- Год издания: 2021
- Издательство: John Wiley & Sons Inc.
- Местоположение издательства: United States
- Первая страница: 837
- Последняя страница: 844
- Номер статьи: pi.6171
- DOI: 10.1002/pi.6171
- Аннотация: The immobilization of a broad‐spectrum antibiotic amikacin on macromolecules of dextran previously modified with epichlorohydrin is described. It is shown that the release of amikacin is observed only in the presence of dextranase, which is produced by bacteria. For the first time, biocomposite materials based on the Glisson capsule of the liver and the pericardium, containing a layer of grafted dextran acting as a carrier of amikacin and capable of releasing amikacin derivatives that have antibacterial activity in the case of infection, have been developed. It was found that the release rate of amikacin derivatives formed in the presence of dextranase is determined by diffusion and is inversely proportional to the squared thickness of the dextran‐containing layer on the surface of biocomposite materials.
- Добавил в систему: Лусс Анна Леонидовна