The formation of quasi-regular polymeric network of cross-linked sulfobutyl ether derivative of β-cyclodextrin synthesized with moxifloxacin as a template

Skuredina, A.A.; Tychinina, A.S.; Le-Deygen, I.M.; Golyshev, S.A.; Belogurova, N.G.; Kudruashova, E.V.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 апреля 2021 г.

Авторы: Skuredina A.A., Tychinina A.S., Le-Deygen I.M., Golyshev S.A., Belogurova N.G., Kudruashova E.V.
Журнал: Reactive and Functional Polymers
Том: 159
Номер: February
Год издания: 2021
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 104811
DOI: 10.1016/j.reactfunctpolym.2021.104811
Аннотация: Sulfobutyl ether derivative of β-cyclodextrin, cross-linked in the presence of antibacterial drug moxifloxacin, forms polymeric nanoparticles (50–150 nm in diameter), with highly efficient (up to 85%) encapsulation of the drug. Cyclodextrins (CyDs) have been known for their ability to accommodate a wide range of organic molecules in their inner cavity, leading to «guest-host» inclusion complexes. Here, we show that in the case of highly cross-linked complex a substantial part of moxifloxacin molecules can be captured by the polymer's network (i.e. encapsulated in the growing 3D structure) rather than absorbed by the CyD's inner cavity. This is accompanied by dramatic changes in moxifloxacin's release kinetics profile: depending on pH, 30–100% of the drug is released from the polymer network within a week. Whereas in the case of moxifloxacin absorption on pre-synthesized CyD polymer matrix, 50% release normally occurs within hours. In vitro studies on Escherichia coli demonstrate that the moxifloxacin in highly cross-linked nanoparticle can preserve over 50% of antibacterial activity for at least 7 days, whereas the same amount of free moxifloxacin, as well as its «guest-host» complex with CyD, is inactive at this time point. The nanoparticles' ability to adhere to the bacterial cell wall may contribute to the higher activity of the smaller amount of the drug, emphasizing the potential relevance of this approach for the development of new pharmaceutical formulations.
Добавил в систему: Скуредина Анна Алексеевна

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The formation of quasi-regular polymeric network of cross-linked sulfobutyl ether derivative of β-cyclodextrin synthesized with moxifloxacin as a templateстатья

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