Mitochondria-Targeted  Rechargeable Antioxidants as  Potential Anti-Aging Drugs

Pasyukova, E.G.; Feniouk, B.A.; Skulachev, V.P.

Авторы: Pasyukova E.G., Feniouk B.A., Skulachev V.P.
Сборник: Anti-aging Drugs: From Basic Research to Clinical Practice
Серия: RSC Drug Discovery
Глава в коллективной монографии
Год издания: 2017
Издательство: Royal Society of Chemistry
Местоположение издательства: United Kingdom
Первая страница: 205
Последняя страница: 227
DOI: 10.1039/9781782626602-00205
Аннотация: Initially regarded solely as “power plants of the living cell”, mitochondria are now also acknowledged as key regulators of cell survival, death, and ageing. Mitochondrial malfunction correlates with aging in a broad variety of species, including yeast, invertebrates and mammals. An important consequence of the mitochondrial malfunction is an increase in the level of reactive oxygen species (ROS). Excessive level of mitochondrial ROS (mROS) results in imbalance of regulatory mitochondrial pathways, oxidative stress, and cell death, which triggers several age-related pathologies. Mitochondria-targeted rechargeable antioxidants (e.g. SkQ1, SkQR, MitoQ) are promising candidates for development of therapeutic drugs capable of suppressing mitochondria-initiated oxidative stress and thereby promoting healthy aging and longevity. In this review, we focus on the studies of mitochondria-targeted rechargeable antioxidants in animal models, with a special focus on experiments with Drosophila melanogaster.
Добавил в систему: Фенюк Борис Александрович

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Mitochondria-Targeted Rechargeable Antioxidants as Potential Anti-Aging Drugsстатья

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