Direct Synthesis of Deuterium-Labeled O-, S-, N-Vinyl Derivatives from Calcium CarbideстатьяИсследовательская статья
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Дата последнего поиска статьи во внешних источниках: 9 апреля 2021 г.
Аннотация:A novel methodology for the preparation of trideuterovinyl derivatives of high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide and D2O acted as a D2-acetylene source, and DMSO-d6 was used to complete the formation of the D2C=C(D)–X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biological activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration.