Copper Ions Potentiate a Decrease in the Mitochondrial Membrane Potential in Cultured Cerebellar Granule Neurons during Glucose Deprivationстатья
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Дата последнего поиска статьи во внешних источниках: 22 июля 2017 г.
Аннотация:We showed that glucose deprivation for 35 min induces a decrease in the mitochondrial membrane
potential in cultured cerebellar granule neurons, which was enhanced in the presence of 10 μM copper ions (Cu2+). This was associated with an increase in the free-radical level that was not affected by the noncompetitive antagonist of glutamate NMDA receptors MK-801, which prevented subsequently developing neuronal loss. However, in the presence of glucose, Cu2+ did not affect cell viability. Thus, Cu2+ induced stronger oxidative stress during glucose deprivation than in the presence of glucose, which, in turn, results in mitochondrial damage, glutamate release, glutamate receptor hyperstimulation, and neuronal loss.