Novel bivalent positive allosteric AMPA receptor modulator of bis-amide seriesстатья
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Дата последнего поиска статьи во внешних источниках: 17 июня 2021 г.
Аннотация:A series of bis-amides of bis(aminoalkyl)benzenes anddiaminoalkanes were synthesized. Positive modulation of kainate-induced transmembrane currents was registered on Purkinje neurons for isobutyric acid derivative with 1,4-bis(aminomethyl)benzene linker (40% potentiation at 1 nm). This compound also demonstrated a neuroprotective effect at 0.1 nm in an oxidative stress model in HT-22 cells when applied 24 h before H2O2.