Stimulus-sensitive liposomal delivery system based on new 3,7-diazabicyclo[3.3.1]nonane derivatives

Veremeeva, P.N.; Zaborova, O.V.; Grishina, I.V.; Makeev, D.V.; Timoshenko, V.A.; Palyulin, V.A.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 июня 2021 г.

Авторы: Veremeeva Polina N., Zaborova Olga V., Grishina Irina V., Makeev Dmitriy V., Timoshenko Vadim A., Palyulin Vladimir A.
Журнал: Bioorganic and Medicinal Chemistry Letters
Том: 39
Год издания: 2021
Издательство: Pergamon Press Ltd.
Местоположение издательства: United Kingdom
Первая страница: 127871
Номер статьи: 127871
DOI: 10.1016/j.bmcl.2021.127871
Аннотация: 3,7-Diazabicyclo[3.3.1]nonane scaffold can serve as a basis for the design of molecular switches stimulating the fast release of water soluble compounds under the influence of external factors from the liposomal containers having those switches incorporated into the lipid bilayer. It was demonstrated that liposomes having 3,7-dihexadecyl-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one (3) incorporated into the liposomal membrane sharply increase the permeability upon pH decrease from 7.4 to 6.5, and compound 3 can serve as a pH-sensitive agent in the bilayer of liposomal nanocontainers. Similar but less pronounced effect was shown for liposomes modified with 3,7-bis(methyldodecylaminoacetyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonane (5) and 3,7-didodecylsulfonyl-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one (4). The structure (morphology) and size of modified liposomes were studied with scanned transmission electron microscopy.
Добавил в систему: Палюлин Владимир Александрович

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Stimulus-sensitive liposomal delivery system based on new 3,7-diazabicyclo[3.3.1]nonane derivativesстатья

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