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Osseointegration evaluation of UHMWPE and PEEK-based scaffolds with BMP-2 using model of critical-size cranial defect in mice and push-out testстатья
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 июля 2021 г.
- Авторы: Senatov F., Maksimkin A., Chubrik A., Kolesnikov E., Orlova P., Krivozubov M., Nikitin K., Gromov A., Karyagina A.
- Журнал: Journal of the Mechanical Behavior of Biomedical Materials
- Том: 119
- Год издания: 2021
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Номер статьи: 104477
- DOI: 10.1016/j.jmbbm.2021.104477
- Аннотация: It the present study the push-out mechanical test was adopted for mouse model of implantation in critical-sizecranial defects to evaluate the effectiveness of implant-skull fusion. As implants, disks of porous ultra-highmolecular weight polyethylene (UHMWPE) and polyetheretherketone (PEEK) with hydroxylapatite (HA) withand without loading of recombinant bone morphogenetic protein-2 (BMP-2) were used. Implantation resultswere evaluated using histology and micro-computed tomography (micro-CT). In the case of both UHMWPE/HAand PEEK/HA, BMP-2 loading resulted in a signifiant increase in the amount of bone tissue in the implantationarea, especially at the edges of the defect, and an increase in the value of BV/TV (bone volume/tissue volume)during micro-CT. There was a high correlation of BV/TV values with the maximum load and elastic modulusmeasured during the puch-out test. The maximum load values showed good convergence within the groups andare comparable to the maximum load values obtained by other authors in the rat model of implantation incritical-size cranial defects. An adapted push-out test can be used to evaluate the quality of osseointegration ofthe implanted materials.
- Добавил в систему: Карягина-Жулина Анна Станиславовна