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Дата последнего поиска статьи во внешних источниках: 4 июня 2021 г.
Аннотация:We analysed spatiotemporal properties of Ca2+ signals in protoplasmic astrocytes in the CA1 stratum radiatum of hippocampal slices from young (2–3 months old) mice housed in control conditions or exposed to a caloric restriction (CR) diet for one month. The astrocytic Ca2+ events became shorter in duration and smaller in size; they also demonstrated reduced velocity of expansion and shrinkage following CR. At the same time, Ca2+ signals in the astrocytes from the CR animals demonstrated higher amplitude and the faster rise and decay rates. These changes can be attributed to CR-induced morphological remodelling and uncoupling of astrocytes described in our previous study. CR-induced changes in the parameters of Ca2+ activity were partially reversed by inhibition of gap junctions/hemichannels with carbenoxolone (CBX). The effect of CBX on Ca2+ activity in CR-animals was unexpected because the diet already decreases gap junctional coupling in astrocytic syncytia. It may reflect the blockade of hemichannels also sensitive to this drug. Thus, CR-induced morphological remodelling of astrocytes is at least partly responsible for changes in the pattern of Ca2+ activity in the astrocytic network. How such changes in spatiotemporal Ca2+ landscape can translate into astrocytic physiology and neuron-glia interactions remains a matter for future studies.