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Perturbed Angular Correlation as a Tool to Study Precursors for Radiopharmaceuticalsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 апреля 2024 г.
- Авторы: Kurakina E.S., Radchenko V., Belozub A.N., Bonchev G., Bozhikov G.A., Velichkov A.I., Stachura M., Karaivanov D.V., Magomedbekov E.P., Filosofov D.V.
- Журнал: Inorganic Chemistry
- Том: 59
- Номер: 17
- Год издания: 2020
- Издательство: American Chemical Society
- Местоположение издательства: United States
- Первая страница: 12209
- Последняя страница: 12217
- DOI: 10.1021/acs.inorgchem.0c01208
- Аннотация: One of the key components of radiopharmaceuticals for targeting imaging and therapy is a stable bifunctional chelating system to attach radionuclides to selective delivery systems. After-effects of radioactive decay can cause the release of a radioactive isotope from its chelation agent. Perturbed angular correlation (PAC) of γ-rays has become a unique technique to study the behavior of complexes formed between a chelating agent and radionuclide in vivo (in real time) over a relevant range of concentrations (10-12 M). In the present work, four radionuclides, 111In, 111mCd, and 152, 154Eu, were investigated with diethylenetriaminepentaacetic acid (DTPA) at different pH values to determine the stability constants of the complexes as well as the effects of post-decay processes, which play a major role in determining the suitability of these complexes for application as radiopharmaceuticals (e.g., in vivo generators). The study provides a convenient parameter for the characterization of radionuclide-chelator systems using the PAC method. PAC is proven to be a suitable tool to study novel chelators and radiopharmaceutical precursors attached to radiometals. Copyright © 2020 American Chemical Society.
- Добавил в систему: Магомедбеков Эльдар Парпачевич