Formation of biomolecular condensates: regulation of embryogenesis at the cellular levelстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 сентября 2021 г.
Аннотация:Many morphogenetic processes during ontogenesis are determined by changes in the structure and functions of embryonic cells. The greatest plasticity of the cellular organization is given by membrane-less organelles or biomolecular condensates, which can be formed in the nucleus or cytoplasm by the mechanism of liquid–liquid phase separation. The flexibility of biogenesis of biomolecular condensates and the high dynamics of their components make it possible to change the cellular organization quickly, which leads to changes in the fate of cells, and, as a result, in the course of embryogenesis. In this review, using the example of germ granules, one of the types of membrane-less structures, the relationship between the plasticity of cellular organization and the implementation of early embryogenesis processes is discussed.