DNA (Gd3+): magnetic properties of neutron absorption agent

Авторы: Nikiforov V.N., Koksharov Yu A.
Сборник: Book of Abstract of Moscow International Conference of Magnetism MISM-2011, August 21-25, 2011, Moscow, Russia
Серия: Moscow International Symposium on Magnetism
Тезисы
Год издания: 2011
Место издания: MSU Moscow, MSU
Первая страница: 776
Аннотация: 157Gd is a potential perspective agent for neutron capture cancer therapy. Gd bound to DNA is actual task for use in EPR and NMR investigations because gadolinium ions could be detected as molecular magnetic marker in diagnostics. In the presented work the calculation of concentration of gadolinium in DNA was provided on the base on the SQUID magnetic susceptibility experiments and EPR experiments. The SQUID and EPR data support the fact that Gd – DNA binding for plasmid and chelate DNA takes place. The magnetic investigations gives us opportunity to calculate the concentration of DNA binded Gd3+ ions. The magnetic results presented are in good accordance with neutron capture data.
Добавил в систему: Никифоров Владимир Николаевич

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