|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Ca and Zn impact on cardiac autonomic activity in healthy urban young adultsтезисы доклада Тезисы
- Авторы: Tymchenko S., Bogdanova A., Baranovskaya N., Evstafeva E.
- Сборник: Scientific Research Abstracts International Meeting of Geohealth Scientists GHC 2020
- Том: 10
- Тезисы
- Год издания: 2020
- Место издания: Digilabs Bari, Italy
- Первая страница: 47
- Последняя страница: 47
- Аннотация: Despite the measures taken to reduce the risk and consequences of anthropogenic environmental pollution on human health, contamination of urban territories is still on its rise. Studies conducted among adults occupationally exposed to heavy metals demonstrate their negative impact on the autonomic control of the cardiac activity while the results among healthy adults under background exposure are less consistent. Thereby we evaluated the influence of background Sr exposure related to Ca and Zn content on heart rate variability (HRV) in healthy individuals (Simferopol, Russian Federation). Concentration of Sr, Ca, Zn in hair was determined in 79 healthy individuals (34 males and 45 females; 18.7±0.7 year old) using the highly-sensitive nuclear-physical method of neutron activation analysis with thermal neutrons irradiation at Tomsk’s research nuclear reactor (National Research Tomsk Polytechnic University). To assess the autonomic control of the cardiac activity five-minute HRV recordings by three-lead electrocardiography (Cardio, Ukraine) were obtained at rest in supine position followed by analysis of standard time and frequency domain HRV parameters. Median hair Ca and Zn levels were 1053.0 μg/g (interquartile range (IQR): 516.0-1849.0 μg/g) and 138.0 μg/g (IQR: 111.0-163.0 μg/g) respectively. Deficiency of Ca and Zn was observed in 8 and 26 individuals and excess – in 30 and 13 individuals, respectively. Sr concentrations exceeded normal values only in 5 individuals ranging between 6.6 to 9.5 μg/g with the median hair Sr concentration equal to 5.0 μg/g (IQR: 5.0-5.0 μg/g) in the entire group. The results showed that the median hair Ca levels for males and females were 537.0 μg/g (IQR: 412.0-774.0) and 1691.0 μg/g (IQR: 1053.0-2514.0) respectively (p<0.001). No significant gender differences were detected for Zn and Sr. HRV assessed with both time and frequency domain approaches demonstrated that all the parameters were within the normal ranges with no significant differences in males and females. Significant associations between hair elements’ concentrations and HRV parameters were observed only for Sr using Spearman’s rank-order correlation. The correlation coefficients revealed for the LFn (r=-0.28, p=0.012), HFn (r=0.28, p=0.012), LF/HF (r=-0.029, p=0.011) at rest and Sr hair concentration suggest higher resting-state HRV in individuals with greater Sr levels and relative balance shift where parasympathetic activity significantly predominates. Observed Sr effects could be enhanced by the altered Ca and Zn levels in examined population suggesting that extent of the health effects of Sr exposure might depend on levels of essential elements. Normalizing Ca and Zn levels in the body could be an effective strategy aimed at attenuating the negative impact of Sr, thus further measures need to be supported by further research.
- Добавил в систему: Богданова Анна Михайловна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | SRA10_Geohealth_2020_otdelno.pdf | 7,0 МБ | 28 мая 2021 [Bogdanova_Anna_Physio] |