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Pharmacogenetics of antipsychotics in adolescents with acute psychotic episode during first 14 days after admission: effectiveness and safety evaluationстатья
Дата последнего поиска статьи во внешних источниках: 27 октября 2021 г.
- Авторы: Ivashchenko Dmitriy V., Khoang Sofi Z., Makhmudova Bakhu V., Buromskaya Nina I., Shimanov Pavel V., Deitch Roman V., Akmalova Kristina A., Shuev Grigoriy N., Dorina Irina V., Nastovich Marina I., Shagovenko Eugenia N., Grishina Elena A., Savchenko Lyudmila M., Shevchenko Yuriy S., Sychev Dmitriy A.
- Журнал: Drug Metabolism and Personalized Therapy
- Том: 35
- Номер: 2363-8915
- Год издания: 2020
- Издательство: Walter de Gruyter
- Местоположение издательства: Berlin, Germany
- Первая страница: 1
- Номер статьи: 32827391
- DOI: 10.1515/dmpt-2020-0102
- Аннотация: Objectives Prediction of the antipsychotic's effectiveness is a relevant topic in the field of personalized medicine. Methods The research design of this study is a prospective observation with posthoc analysis of associations of genetic polymorphisms with safety parameters and effectiveness of antipsychotic therapy. We observed 53 adolescents with an acute psychotic episode which were prescribed antipsychotics for 14 days. We evaluated the effectiveness of antipsychotics with the Positive and Negative Symptoms Scale and the safety with the UKU Side Effects Rating Scale, Simpson-Angus Scale, and Barnes Akathisia rating scale. We genotyped CYP3A4*22 (rs2740574), CYP3A5*3 (6986A>G, rs7767746), CYP2D6*4, *9, *10 (rs3892097, rs1065852), ABCB1 1236C>T (rs1128503), 2677G>T/A (rs2032582), 3435C>T (rs1045642), DRD2 (rs1800497), DRD4 (rs1800955), HTR2A (rs6313) by the real-time polymerase chain reaction method. Results We found significantly more frequent "increased dream activity" between CYP2D6 intermediate metabolizers and normal metabolizers (54 vs. 22%; p=0.043). The «increased duration of sleep» was more often observed in homozygotes TT of ABCB1 2677G>T/A (50 vs. 15.8%, p=0.006) and TT of 3435C>T (41.7 vs. 8.2%, p=0.007). Conclusions We found that CYP2D6 and ABCB1 polymorphisms were associated with the safety of antipsychotics in adolescents with an acute psychotic episode.
- Добавил в систему: Махмудова Баху Викторовна