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Transcriptomic signatures and upstream regulation in human skeletal muscle induced by inactivity and aerobic exercise: a meta-analysisтезисы доклада Тезисы
- Авторы: Popov D.V., Makhnovskii P.A., Bokov R.O., Kolpakov F.A., Vinogradova O.L.
- Сборник: Авиакосмическая и экологическая медицина
- Серия: 1/1 special
- Том: 55
- Тезисы
- Год издания: 2021
- Издательство: Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации Институт медико-биологических проблем Российской академии наук
- Местоположение издательства: Москва
- Первая страница: 120
- Последняя страница: 120
- Аннотация: Inactivity is associated with the development of numerous disorders. Regular aerobic exercise is broadly used as a keyintervention to prevent and treat these pathological conditions. In our meta-analysis we aimed to identify and compare i)the transcriptomic signatures related to in-activity, regular and acute aerobic exercise in human skeletal muscle, and ii) thebiological effects and transcription factors associated with these transcriptomic changes. A standardized workflow with robustcut-off criteria was used to analyse 27 transcriptomic datasets for the vastus lateralis muscle of healthy humans subjectedto inactivity, regular and acute aerobic exercise. We evaluated a role of transcriptional regulation in the phenotypic changesdescribed in the literature. The responses to chronic interventions (inactivity and regular training) partially correspond to thephenotypic effects. While acute exercise induces changes that are mainly related to the regulation of gene expression, includinga strong enrichment of several transcription factors (most of which are related to the ATF/CREB/AP-1 superfamily), and amassive increase in the expression levels of genes encoding transcription factors and co-activators. Overall, the adaptationstrategies of skeletal muscle to decreased and increased levels of physical activity differ in direction and demonstrate qualitativedifferences that are closely associated with the activation of different sets of transcription factors.This research was funded by the Russian Foundation for Basic Research (RFBR), grant No. 17-00-00308K (17-00-00242)and No. 19-315-90135.
- Добавил в систему: Боков Роман Олегович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Abstract_Book_HIS_2021.pdf | 3,3 МБ | 16 июня 2021 [BokovRO] |