Association of MAOA, CCK, COMT, TPH1, SERT, PDE4B with panic disorder in patients from the Moscow population

Afonchikova, E.; Azimova, J.E.; Fokina, N.M.; Kokaeva, Z.G.; Kochetkova, T.O.; Kondratieva, N.S.; Rudko, O.I.; Tabeeva, G.R.; Klimov, E.A.

Авторы: Afonchikova E., Azimova J.E., Fokina N.M., Kokaeva Z.G., Kochetkova T.O., Kondratieva N.S., Rudko O.I., Tabeeva G.R., Klimov E.A.
Сборник: 38th FEBS Congress, Saint Petersburg, Russia, July 6–11, 2013
Серия: FEBS Journal 280 (Suppl. 1) (2013) 3–617
Том: 280
Год издания: 2013
Место издания: Blackwell Publishing Inc United Kingdom
Первая страница: 343
Последняя страница: 344
DOI: 10.1111/febs.12340
Аннотация: Background: Panic disorder (PD) is a disease characterized by the appearance of spontaneous panic attacks a few times a year, up to several times per day, and fear out of their occurrence. Genetic factors play a role in the pathogenesis of PD (heritability value 48%). However, the molecular-genetic basis of the disease have been studied very little. Published data indicate that polymorphic variants of genes encoding key enzymes of neuromediatory systems, neurotransmitters and their receptors play a role in development of PD. We have selected the basic proteins, gene polymorphisms that may have an impact on the development of PD: neuropeptide cholecystokinin (CCK); monoamine oxidase A (MAOA); catechol-O-methyltransferase (COMT); solute carrier family 6 (SLC6A4 or 5-HTT); serotonin transporter (SERT), tryptophan hydroxylase 1 (TPH1); phosphodiesterase 4В (PDE4B). Objectives: Assess the contribution to the development of PD the alleles: STR in 5’-region of ССК gene, VNTR in 5’-region of МАОА gene, SNPs in genes COMT (rs4680), 5-HTT (rs3813034), SERT (rs3813034), TPH1 (rs1800532), PDE4B (rs502958 и rs1040716). Methods: Blood samples of patients diagnosed with PD (n = 82) and blood samples of unexamined people (control) living in Moscow and the Moscow region (n = 192). STR and VNTR alleles distinguished by fragment analysis, SNPs detected by Real-Time. Results: An analysis of STR in CCK gene and the VNTR in MAOA gene was identified combination of alleles (S / M) is more common in a sample of patients with PD compared with control sample. Genotype AC of SNP rs3813034 (SERT) - is less common in patients with PD, compared with the control samples. Allele frequencies of gene COMT, 5-HTT, TPH1 and PDE4B did not differ between the groups of patients and controls. Conclusions: These data suggest that polymorphisms in CCK, MAOA and SERT genes can be associated with PD. Further studies could highlight the association between these polymorphisms and the appearance of panic disorder.
Добавил в систему: Климов Евгений Александрович

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ИНХС РАН

Association of MAOA, CCK, COMT, TPH1, SERT, PDE4B with panic disorder in patients from the Moscow populationстатья Тезисы

Прикрепленные файлы