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Protein Folding as Flow across a Network of Folding−Unfolding Pathways. 2. The “In-Water” Caseстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 июля 2021 г.
- Авторы: Ivankov Dmitry N., Finkelstein Alexei V.
- Журнал: Journal of Physical Chemistry B
- Том: 114
- Номер: 23
- Год издания: 2010
- Издательство: American Chemical Society
- Местоположение издательства: United States
- Первая страница: 7930
- Последняя страница: 7934
- DOI: 10.1021/jp912187w
- Аннотация: This paper, second in the series, extends our analysis of networks of protein folding-unfolding pathways in vitro from the equilibrium, analytically the simplest, to "in-water" conditions, i.e., to the case when the native state of a protein is, as a rule, much more stable than the unfolded one. Protein folding rates and folding nuclei determined for such "physiological" conditions are of special biological and medical interest because of their relevance to misfolding diseases and other folding-related disorders. Given the native protein structures and their experimental in-water stabilities, the previously developed general theory (see paper 1 of this series) is applied here to compute the in-water folding and unfolding rates and outline the folding nuclei. Agreement between these calculations and experiment appears to be reasonably good.
- Добавил в систему: Финкельштейн Алексей Витальевич