Effect of dipyridamole on cerebral blood flow and cerebral oxygen saturation in patients with atherosclerotic carotid artery lesions

Yankevich, D.S.; Piradov, M.A.; Borisenko, V.V.

Авторы: Yankevich D.S., Piradov M.A., Borisenko V.V.
Журнал: European Journal of Neurology
Том: 10
Номер: Suppl. 1
Год издания: 2003
Издательство: Blackwell Publishing Inc.
Местоположение издательства: United Kingdom
Первая страница: 49
Последняя страница: 49
Номер статьи: P1015
Аннотация: Dipyridamole infusion (DI) is commonly used to assess the myocardial perfusion in patients with coronary artery disease.In this study we evaluated the effects of dipyridamole on regional cerebral blood flow (rCBF) and cerebral oxygen saturation (rSO2) in 11 patients with asymmetric asymptomatic atherosclerotic internal carotid artery (ICA) lesions.Stenosis of one ICA was more than 60%, stenosis of another ICA was less than 50%. Asymmetry was greater than 20%.We semiquantitatively evaluated rCBF and rCBF reactivity to DI using a 99mTc hexamethyl-propyleneamine oxime single photon emission computer tomography (99mTc-HMPAO SPECT). rSO2 and rSO2 reactivity were studied using nearinfrared spectroscopy (NIRS). The time of maximal rSO2 response to DI was Me (25%, 75%) ¼ 11(9; 12 min) from the beginning of DI. The change of the rSO2 during DI correlated significantly with the resting and DI rSO2 values. Two of four patients, who showed relative means of rSO2 reactivity less than 4%, had also rCBF asymmetry greater than 10% after DI. The other patients had normal CBF reactivity to DI.Nevertheless one patient, with symmetric resting rCBF and normal CBF reactivity to DI, had a low rSO2 value both before and after DI and low rSO2 reactivity. He was considered to have symmetric low cerebral perfusion and cerebrovascular reactivity to DI. DI is believed to be a useful test to assess cerebrovascular reactivity. NIRS both with and without DI may be used as an addition to 99mTc-HMPAO SPECT semiquantitative method of brain hemodynamics adequacy evaluation.
Добавил в систему: Янкевич Дмитрий Станиславович

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Effect of dipyridamole on cerebral blood flow and cerebral oxygen saturation in patients with atherosclerotic carotid artery lesionsстатья Тезисы

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