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Modeling Hepatotropic Viral Infections: Cells vs. Animalsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 сентября 2021 г.
- Авторы: Khoshdel-Rad Niloofar, Zahmatkesh Ensieh, Bikmulina Polina, Peshkova Maria, Kosheleva Nastasia, Bezrukov Evgeny A., Sukhanov Roman B., Solovieva Anna, Shpichka Anastasia, Timashev Peter, Vosough Massoud
- Журнал: Cells
- Том: 10
- Номер: 7
- Год издания: 2021
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1726
- Последняя страница: 1726
- DOI: 10.3390/cells10071726
- Аннотация: The lack of an appropriate platform for a better understanding of the molecular basis of hepatitis viruses and the absence of reliable models to identify novel therapeutic agents for a targeted treatment are the two major obstacles for launching efficient clinical protocols in different types of viral hepatitis. Viruses are obligate intracellular parasites, and the development of model systems for efficient viral replication is necessary for basic and applied studies. Viral hepatitis is a major health issue and a leading cause of morbidity and mortality. Despite the extensive efforts that have been made on fundamental and translational research, traditional models are not effective in representing this viral infection in a laboratory. In this review, we discuss in vitro cell-based models and in vivo animal models, with their strengths and weaknesses. In addition, the most important findings that have been retrieved from each model are described.
- Добавил в систему: Тимашев Петр Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | cells-10-01726.pdf | 3,2 МБ | 9 августа 2021 [TPS_SU] |