Аннотация:Факторы риска длительного covid у ранее госпитализированных детей с использованием глобального протокола последующего наблюдения ISARIC: проспективное когортное исследование
Исмаил M Османов , Екатерина Спиридонова , Полина Бобкова , Aysylu Gamirova , Анастасия Шихалева , Маргарита Андреева , Олег Blyuss , Ясмин Эль-Taravi , Одри DunnGalvin , Pasquale Comberiati , Diego G Перони , Кристиан Apfelbacher , Джон Genuneit , Людмила Mazankova , Александра Мирошина ,Евгения Чистякова , Эльмира Самитова , Светлана Borzakova , Елена Бондаренко , Анатолий Корсунский , Ирина Конова , Сара Вульф Hanson , Гейл Карсон , Луиза Зигфрид , Джанет T Скотт , Мэттью Greenhawt , Элизабет Уиттакер , Елена Garralda , Оливия Swann , Данило Buonsenso , Даша E Николс , Фрэнсис Симпсон , Кристина Джонс , Малкольм Дж. Семпл , Джон О Уорнер , Тео Вос , Пьеро Оллиаро , Даниэль Мунблит
Сеченов Группа исследований StopCOVID
Европейский респираторный журнал 2021; DOI:10.1183 / 13993003.01341-2021
Background The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.Methods This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.Findings 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3–15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and “12–18 years” (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).Interpretation A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.