Role of NMDA Receptors and Protein Synthesis in the Conditioned Aversion Learning in Young Chicksстатья
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Дата последнего поиска статьи во внешних источниках: 15 сентября 2021 г.
Аннотация:The brain mechanisms underlying conditioned aversion learning in birds were studied using
experimental model in young chicks. The learning consisted of a conditioning stimulus presentation
followed by a delayed sickness-inducing treatment reinforcement. Intraventricular
administration of an NMDA receptor antagonist MK-801, a protein synthesis inhibitor anisomycin,
or an inhibitor of glycoprotein fucosylation 2-deoxygalactose just before presentation
of the conditioning stimulus prevented aversion learning. Injections of the same chemicals
before reinforcement did not affect learning. The obtained results show that the investigated
mechanisms underlying aversion learning were critical at the early stage of memory formation.
Later processes of association of the conditioning stimulus with the reinforcement appear to
be independent of the NMDA receptors and protein synthesis/glycosylation, or alternatively
to be located in other brain areas.