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THE BIOCHEMICAL BLOOD PARAMETERS IN TYPE 1 DIABETES MELLITUS FEMALE PATIENTS OF DIFFERENT AGES AND ETHNICITYстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 15 сентября 2021 г.
- Авторы: Darenskaya M.A., Shemyakina N.A., Namokonov E.V., Kolesnikov S.I., Kolesnikova L.I.
- Журнал: Diabetes Technology and Therapeutics
- Том: 23
- Номер: s2
- Год издания: 2021
- Издательство: Mary Ann Liebert Inc.
- Местоположение издательства: United States
- Первая страница: 224
- Последняя страница: 224
- DOI: 10.1089/dia.2021.2525.abstracts
- Аннотация: Background and Aims: Due to the widespread and the severity of complications type 1 diabetes mellitus (T1DM) is considered the acute problem and priority for the many countries health care. Features of T1DM course depend on many factors, including ethnic, racial affiliation and region of residence. The aim of this study was to reveal the different ages and ethnicity T1DM patients several biochemical components peculiarities.Methods: The Caucasian and Asian T1DM patients (17 adolescent girls and 20 reproductive age women) biochemical parameters were evaluated in comparison with corresponding age control groups. Spectrophotometric, fluorometric and statistic methods were applied.Results: Caucasian adolescent girls with T1DM had higher diene conjugates values (by 2 times), thiobarbituric acid reactants (by 1.8 times), oxidative stress coefficient (by 3.4 times), lactate level (by 1.4 times) and the ratio lactate/pyruvate (by 1.9 times), in comparison with same age Asian patients. In Caucasian women with T1DM the following differences with Asian T1DM patients were observed: content of total lipids (1.5 times) and unsaturated double bond substrates (by 1.4 times) increase and blood total antioxidant activity level decrease (by 32%).Conclusions: Oxidative stress intensity depends on T1DM patient ethnicity. The lack of accumulation of toxic lipid peroxidation products in representatives of the Asian ethnic group may be a positive sign in disease further course and vascular complications prognosis.
- Добавил в систему: Колесников Сергей Иванович