Sensitization of MCF-7 breast cancer cells to the apoptotic effect of estradiolстатья
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Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
Авторы:
Shcherbakov A.M. ,
Lobanova Yu S. ,
Shatskaya V.A. ,
Onopchenko O.V. ,
Gaspar’yan A.V.,
Gershtein E.S. ,
Krasil’nikov M.A.
Журнал:
Bulletin of Experimental Biology and Medicine
Том:
141
Номер:
3
Год издания:
2006
Издательство:
Springer Nature
Местоположение издательства:
Switzerland
Первая страница:
357
Последняя страница:
360
DOI:
10.1007/s10517-006-0170-8
Аннотация:
A new substrain of hormone-resistant MCF-7/T breast cancer cells was selected after long-term culturing of estrogen-dependent MCF-7 cells in the presence of tamoxifen. These cells were resistant to the growth-stimulating and cytostatic effects of estradiol and tamoxifen, respectively. MCF-7/T cells gained paradoxical sensitivity to the apoptotic effect of estradiol. Estradiol stimulated p53 expression and decreased DNA-binding activity of NF-ОєB. Our findings provide indirect evidence that these proteins are involved in the regulation of estrogen-induced apoptosis. These results indicate that tamoxifen-resistant breast cancer cells can be sensitized to the apoptotic effect of estradiol. The data form a basis for the development of new methods of endocrine therapy for breast cancer patients. В© Springer Science+Business Media, Inc. 2006.
Добавил в систему:
Герштейн Елена Сергеевна