Supercritical Carbon Dioxide Extraction of Four Medicinal Mediterranean Plants: Investigation of Chemical Composition and Antioxidant Activity

Čižmek, L.; Kralj, M.B.; Čož‐Rakovac, R.; Mazur, D.; Ul’yanovskii, N.; Likon, M.; Trebše, P.

Авторы: Čižmek Lara, Kralj Mojca Bavcon, Čož‐Rakovac Rozelindra, Mazur Dmitrii, Ul’yanovskii Nikolay, Likon Marko, Trebše Polonca
Журнал: Molecules
Том: 26
Номер: 18
Год издания: 2021
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 5697
DOI: 10.3390/molecules26185697
Аннотация: With everyday advances in the field of pharmaceuticals, medicinal plants have high priorityregarding the introduction of novel synthetic compounds by the usage of environmentallyfriendly extraction technologies. Herein, a supercritical CO2 extraction method was implemented inthe analysis of four plants (chamomile, St. John’s wort, yarrow, and curry plant) after which thenon‐targeted analysis of the chemical composition, phenolic content, and antioxidant activity wasevaluated. The extraction yield was the highest for the chamomile (5%), while moderate yields wereobtained for the other three plants. The chemical composition analyzed by gas chromatographyhigh‐resolution mass spectrometry (GC‐HRMS) and liquid chromatography‐high‐resolution massspectrometry (LC‐HRMS) demonstrated extraction of diverse compounds including terpenes andterpenoids, fatty acids, flavonoids and coumarins, functionalized phytosterols, and polyphenols.Voltammetry of microfilm immobilized on a glassy carbon electrode using square‐wave voltammetry(SWV) was applied in the analysis of extracts. It was found that antioxidant activity obtained bySWV correlates well to 1,1‐diphenyl‐2‐picrylhidrazine (DPPH) radical assay (R2 = 0.818) and ferricreducing antioxidant power (FRAP) assay (R2 = 0.640), but not to the total phenolic content (R2 =0.092). Effective results were obtained in terms of activity showing the potential usage of supercriticalCO2 extraction to acquire bioactive compounds of interest.
Добавил в систему: Мазур Дмитрий Михайлович

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Supercritical Carbon Dioxide Extraction of Four Medicinal Mediterranean Plants: Investigation of Chemical Composition and Antioxidant Activityстатья

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